解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0571-7
更新日期:2018-10-01 00:00:00
abstract::In this Letter, the received date should have been 23 March 2017 instead of 13 April 2018. Authors R.M.K. and O.D.K. were incorrectly denoted as 'equally contributing' authors. The labels for 'control' and 'IFNγ' in Extended Data Fig. 4g were reversed. These have been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0370-1
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07151-0
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 面试
doi:10.1038/d41586-018-07047-z
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 信件
doi:10.1038/d41586-018-07152-z
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07110-9
更新日期:2018-10-01 00:00:00
abstract::Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown. Here we systematically explore interactions between the nucleosome and 220 tr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0549-5
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-06989-8
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07046-0
更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07033-5
更新日期:2018-10-01 00:00:00
abstract::Topological insulators-materials that are insulating in the bulk but allow electrons to flow on their surface-are striking examples of materials in which topological invariants are manifested in robustness against perturbations such as defects and disorder1. Their most prominent feature is the emergence of edge states...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0601-5
更新日期:2018-10-01 00:00:00
abstract::Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone-usher pathway2-5. The outer-membrane usher FimD recruits pilus subunits bound by the chaperone FimC via the periplasmic N-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0587-z
更新日期:2018-10-01 00:00:00
abstract::Change history: In this Letter, the received date should be 20 December 2017, instead of 27 April 2018. This has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0314-9
更新日期:2018-10-01 00:00:00
abstract::The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0462-y
更新日期:2018-09-01 00:00:00
abstract::Understanding ice sheet behaviour in the geological past is essential for evaluating the role of the cryosphere in the climate system and for projecting rates and magnitudes of sea level rise in future warming scenarios1-4. Although both geological data5-7 and ice sheet models3,8 indicate that marine-based sectors of ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-018-0501-8
更新日期:2018-09-01 00:00:00
abstract::Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs after micronuclei spontaneous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0534-z
更新日期:2018-09-01 00:00:00
abstract::Spintronics relies on the transport of spins, the intrinsic angular momentum of electrons, as an alternative to the transport of electron charge as in conventional electronics. The long-term goal of spintronics research is to develop spin-based, low-dissipation computing-technology devices. Recently, long-distance tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0490-7
更新日期:2018-09-01 00:00:00
abstract::CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0500-9
更新日期:2018-09-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type 1 transmembrane domain protein, receptor activity-modifying prote...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0535-y
更新日期:2018-09-01 00:00:00
abstract::Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0497-0
更新日期:2018-09-01 00:00:00
abstract::Quantum light is characterized by distinctive statistical distributions that are possible only because of quantum mechanical effects. For example, single photons and correlated photon pairs exhibit photon number distributions with variance lower than classically allowed limits. This enables high-fidelity transmission ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0478-3
更新日期:2018-09-01 00:00:00
abstract::Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among the most frequent events in human cancers1,2. However, pharmacol...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0343-4
更新日期:2018-08-01 00:00:00
abstract::Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0442-2
更新日期:2018-08-01 00:00:00
abstract::A short, 14-amino-acid segment called SP1, located in the Gag structural protein1, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0396-4
更新日期:2018-08-01 00:00:00
abstract::Living organisms rely on simultaneous reactions catalysed by mutually compatible and selective enzymes to synthesize complex natural products and other metabolites. To combine the advantages of these biological systems with the reactivity of artificial chemical catalysts, chemists have devised sequential, concurrent, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0413-7
更新日期:2018-08-01 00:00:00
abstract::Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0423-5
更新日期:2018-08-01 00:00:00
abstract::53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0362-1
更新日期:2018-08-01 00:00:00
abstract::Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0416-4
更新日期:2018-08-01 00:00:00
abstract::The long-term exchange of volatile species (such as water, carbon, nitrogen and the noble gases) between deep Earth and surface reservoirs controls the habitability of the Earth's surface. The present-day volatile budget of the mantle reflects the integrated history of outgassing and retention of primordial volatiles ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0388-4
更新日期:2018-08-01 00:00:00
abstract::Prized for their ability to rapidly generate chemical complexity by building new ring systems and stereocentres1, cycloaddition reactions have featured in numerous total syntheses2 and are a key component in the education of chemistry students3. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to syn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0391-9
更新日期:2018-08-01 00:00:00
abstract::Gram-negative bacteria possess a complex cell envelope that consists of a plasma membrane, a peptidoglycan cell wall and an outer membrane. The envelope is a selective chemical barrier1 that defines cell shape2 and allows the cell to sustain large mechanical loads such as turgor pressure3. It is widely believed that t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0344-3
更新日期:2018-07-01 00:00:00
abstract::OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain assembly complex) and is critical for preventing auto-inflammatory disease1,2 and embryonic lethality during mouse development3. Here we show that OTULIN promo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0256-2
更新日期:2018-07-01 00:00:00
abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0262-4
更新日期:2018-07-01 00:00:00
abstract::The hot streak-loosely defined as 'winning begets more winnings'-highlights a specific period during which an individual's performance is substantially better than his or her typical performance. Although hot streaks have been widely debated in sports1,2, gambling3-5 and financial markets6,7 over the past several deca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0315-8
更新日期:2018-07-01 00:00:00
abstract::Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0322-9
更新日期:2018-07-01 00:00:00
abstract::In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0231-y
更新日期:2018-07-01 00:00:00
abstract::In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0141-z
更新日期:2018-07-01 00:00:00
abstract::Topological states of matter are characterized by topological invariants, which are physical quantities whose values are quantized and do not depend on the details of the system (such as its shape, size and impurities). Of these quantities, the easiest to probe is the electrical Hall conductance, and fractional values...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0184-1
更新日期:2018-07-01 00:00:00
abstract::In this Article, owing to an error during the production process, in Fig. 1a, the dark blue and light blue wedges were incorrectly labelled as 'G•C → T•A' and 'G•C → A•T', instead of 'C•G → T•A' and 'C•G → A•T', respectively. Fig. 1 has been corrected online. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0070-x
更新日期:2018-07-01 00:00:00
abstract::The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)1,2. Unattached kinetochores control MCC assembly by catalysing a chan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0281-1
更新日期:2018-07-01 00:00:00